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Adlyxin (Lixisenatide)

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Adlyxin Drug Info (Pack with one pen injection x 0.1 mg / ml each)

  • OVERVIEW

    The active component in Adlyxin is lixisenatide which is a glucagon-like peptide-1 receptor agonist. It is injected into the skin to control blood sugar levels.

  • HOW IT WORKS?

    Adlyxin is one the few medicines capable of slowing down the transit time from stomach to intestines to help decrease blood sugar levels. This also works simultaneously with its other actions to help achieve a meaningful reduction in blood sugar levels with a convenient once daily dose. Furthermore, patients can also develop a healthy habit as daily dosing is required at 60 minutes before the first meal of the day.

 

Adlyxin (Lixisenatide)

Adlyxin (Lixisenatide) is a revolutionary injectable prescription medicine that significantly improves blood sugar (glucose) management in adults with type 2 diabetes. This medication is used alongside a healthy diet and exercise to enhance glycemic control and is not recommended for treating type 1 diabetes or diabetic ketoacidosis.

Why Choose Adlyxin (Lixisenatide)?

  • Improved Blood Sugar Control: Helps in managing your blood sugar levels effectively, reducing the risk of diabetes-related complications.

  • Convenient Dosing: The once-daily injection can be taken at any time, offering flexibility and ease of use.

  • Complements Your Diabetes Plan: Works in conjunction with diet and exercise to improve your overall diabetes management strategy.

How to Use Adlyxin (Lixisenatide)?

  • Select an Injection Site: Adlyxin can be injected into your abdomen, thigh, or upper arm. Choose a different site each time to reduce the risk of skin issues.

  • Clean the Injection Site: Use an alcohol swab to clean the skin where you will inject Adlyxin. Allow the skin to dry before proceeding.

  • Prepare the Pen for Injection: Follow the instructions provided with your Adlyxin pen to attach a new needle, prime the pen, and set your dose.

  • Inject Adlyxin: Insert the needle into your skin as taught by your healthcare provider. Press the button on the pen to inject the dose. Hold the button down and count slowly to 10 to make sure you get the full dose.

  • Dispose of the Needle Safely: After injection, carefully remove the needle from the pen. Dispose of it in a puncture-resistant sharps container.

Important Safety Information about Adlyxin

  • Allergy Warning:Do not use Adlyxin if you are allergic to lixisenatide or any of the ingredients in this medication.
  • Medical Conditions:Patients with a personal or family history of medullary thyroid carcinoma (MTC) or those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use Adlyxin.

  • Kidney Problems:Changes in kidney function, including kidney failure, have been reported with the use of Adlyxin. Monitoring kidney function is essential before and during treatment.

  • Gastrointestinal Disease:Adlyxin may affect the speed of food moving through your stomach, so it’s important to discuss any gastrointestinal concerns with your healthcare provider.

Fact Table for Adlyxin

Brand Name Adlyxin (USA)
Generic Name

 Lixisenatide
Drug Class Glucagon-like peptide-1 (GLP-1) receptor agonist
FDA Approval

 Yes, for the treatment of adults with type 2 diabetes.
Indications To improve blood sugar control in adults with type 2 diabetes, along with diet and exercise.
Dosage Form

 Injectable solution (pre-filled pen)
Recommended Dose
 Administered once daily; the dose may be adjusted based on the patient’s medical condition and response to treatment
Administration Time

 Can be taken at any time of day, with or without food.
Mechanism of Action Increases insulin secretion in response to high blood glucose levels, decreases glucagon secretion, and slows gastric emptying.
Major Benefits Improves glycemic control in adults with type 2 diabetes, Flexible dosing schedule, Can be used in combination with other diabetes medications.
Common Side Effects Nausea, Vomiting, Diarrhea, Headache Hypoglycemia (when used with other diabetes medications).
Contraindications History of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), Allergy to lixisenatide or any component of the formulation.
Use in Specific Populations Caution in patients with a history of pancreatitis, Limited data on use in pregnant and breastfeeding women, Not recommended for pediatric use.
Monitoring Requirements

 Blood glucose levels, Renal function, Signs of pancreatitis or allergic reactions.

Common Side Effects of Adlyxin

Like all medications, Adlyxin can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Hypoglycemia
  • Nausea
  • Vomiting
  • Headache
  • Allergic reactions

If you experience any side effects, discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Adlyxin (Lixisenatide)?

You can order Adlyxin (Lixisenatide) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

Frequently Asked Questions

  1. What if I miss a dose?

    If you miss a dose of Lixisenatide, take it within an hour before your next meal if possible. However, if it’s almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Avoid using an extra dose to make up for the missed one.

  2. How is Lixisenatide administered?

    Lixisenatide comes in a pre-filled injection pen to be used once daily, ideally at the same time each day and within an hour before the first meal. It’s injected under the skin (subcutaneously) in the thigh, upper arm, or abdomen. Remember, don’t share your Lixisenatide pen with others, even if the needle has been changed.

  3. What should I know before starting Lixisenatide?

    Before diving in, make sure to tell your doctor about any medical conditions, especially related to the pancreas, kidneys, or liver, and any other medicines you’re taking. If you’re pregnant, planning to become pregnant, or breastfeeding, discuss it with your doctor to weigh the benefits against the risks.

  4. Can Lixisenatide be used with other medications?

    Lixisenatide can slow down the absorption of other medicines. It’s particularly important to take it one hour before or 11 hours after any oral medications to avoid interactions. Always discuss with your healthcare provider about any other medications you’re taking to ensure they won’t interfere with Lixisenatide.

  5. What are the possible side effects of Lixisenatide?

    While it can be a game-changer for many, it’s not without its side effects. These can range from mild, like nausea, vomiting, and diarrhea, to more severe ones, such as pancreatitis, kidney problems, and severe allergic reactions. It’s crucial to speak with your doctor if you experience any side effects.

  6. How does Lixisenatide work?

    It functions as a GLP-1 receptor agonist, which means it works by increasing insulin release in response to high blood sugar levels, decreasing the amount of sugar your liver makes, and slowing down food leaving your stomach to help prevent blood sugar spikes.

  7. What is Lixisenatide and who should use it?

    Lixisenatide, known under the brand name Adlyxin, is a medication for managing type 2 diabetes mellitus. Take proper diet and exercise along with this medicine to improve blood sugar control in adults. It’s not for treating type 1 diabetes or for people with a history of pancreatitis.

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Questions?

References
Lixisenatide [package insert].Bridgewater, NJ: Sanofi-aventis; 2016.

Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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