Depo-Provera (Medroxyprogesterone)

Depo-Provera
Medroxyprogesterone

Source:

Depo-Provera is a prescription injectable solution that contains the active component medroxyprogesterone acetate. This long-acting version of progestin aids in the prevention of pregnancy and is also used to treat specific health conditions as prescribed by a healthcare provider.

Why Choose Depo-Provera (Medroxyprogesterone)?

  • Effective Birth Control: When used as indicated, has an efficacy rate of roughly 99% in preventing conception.
  • Long-lasting: A single injection lasts three months, making it more convenient than daily birth control options.
  • Estrogen-Free: Suitable for ladies who are unable to take estrogen.
  • Versatile Use: It is used for a variety of purposes, including birth control, endometriosis, irregular menstruation, and hormonal imbalances.

How to Use Depo-Provera (Medroxyprogesterone)?

  • Consult a healthcare provider: Discuss your medical history, including current and previous health conditions, as well as any medications or supplements you are taking.
  • Evaluate suitability: Ensure that Depo-Provera is appropriate for your needs and does not offer any health hazards, especially if you have a history of blood clots, unexplained vaginal bleeding, liver disease, breast cancer, or are pregnant.
  • Understand the benefits and risks: Understand the potential side effects, which include menstruation changes, weight gain, and bone density loss over time.
  • Initial Shot Timing: The initial injection should be administered within the first five days of your menstrual cycle to provide rapid protection against pregnancy.
  • Follow-up Injections: Follow-up injections are necessary every 12 weeks (about every three months). It is vital to adhere to this schedule for continued effectiveness.

Important Safety Information about Depo-Provera

  • Not for STD Protection: Depo-Provera does not prevent sexually transmitted infections (STDs). Use condoms to avoid STDs.
  • Missed Injection: If you miss your planned injection, notify your healthcare practitioner right away. You may need to use a different birth control technique until your next injection.
  • Pregnancy Planning: If you intend to become pregnant soon, talk to your doctor about alternate contraception techniques, as fertility may not return immediately after discontinuing Depo-Provera use.

Fact Table for Depo-Provera

Facts Details
Generic Name Medroxyprogesterone Acetate
Brand Name(s) Depo-Provera, Depo-SubQ Provera 104
Drug Class Progestin, Hormonal Contraceptive
FDA Approval Date October 29, 1992, for contraceptive use; other uses approved earlier or later depending on indication
Indications – Contraception – Management of endometriosis-related pain – Part of hormone replacement therapy – Certain types of cancer treatment (e.g., kidney cancer, endometrial cancer)
Administration Route Intramuscular injection (Depo-Provera); Subcutaneous injection (Depo-SubQ Provera 104)
Dosage Form Injectable Suspension
Recommended Dosage – Contraception: 150 mg every 3 months intramuscularly (Depo-Provera) – Endometriosis: Varies based on specific treatment plan
Mechanism of Action Suppresses ovulation increases cervical mucus viscosity and induces endometrial thinning to prevent pregnancy
Common Side Effects – Weight gain – Irregular menstrual periods or no periods at all Headaches – Abdominal pain or discomfort – Dizziness – Decreased libido
Contraindications – Known or suspected pregnancy – Unexplained vaginal bleeding – Active thrombophlebitis or thromboembolic disorders – Liver disease- Known hypersensitivity to medroxyprogesterone acetate or any of its other components
Drug Interactions – Aminoglutethimide (can decrease plasma concentrations) – Drugs inducing hepatic enzymes (e.g., rifampin, St. John’s Wort) may decrease effectiveness
Boxed Warning Prolonged use may result in significant loss of bone density, which is partly reversible upon discontinuation. This risk is greater with a longer duration of use and may not be completely reversible.
Pregnancy Category X (Should not be used during pregnancy as it can cause harm to the fetus)
Storage Store at 20 to 25°C (68 to 77°F); excursions permitted to 15 to 30°C (59 to 86°F)

 

Common Side Effects of Depo-Provera

Like all medications, Depo-Provera (Medroxyprogesterone) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Weight gain
  • Irregular menstrual periods or no periods at all 
  • Headaches
  • Abdominal pain or discomfort
  • Dizziness
  • Decreased libido

If you experience any of these side effects or others, make sure to discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Depo-Provera (Medroxyprogesterone)?

You can order Depo-Provera (Medroxyprogesterone) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

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Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
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