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Harvoni (Ledipasvir / Sofosbuvir)
Harvoni, a breakthrough in Hepatitis C treatment, combines Ledipasvir and Sofosbuvir in one tablet. It is primarily intended to treat chronic Hepatitis C virus (HCV) genotypes 1, 4, 5, and 6 in adults and children over the age of 3. Harvoni’s once-daily oral regimen provides a cure for many patients suffering from this chronic illness, opening a new age of HCV treatment with its high cure rates and simpler therapy schedule.
Why Choose Harvoni (Ledipasvir / Sofosbuvir)?
- High Cure Rate: Harvoni has been reported to cure up to 99% of individuals with Hepatitis C genotypes 1, 4, 5, and 6 in just 12 weeks of treatment, including many patients without or with compensated cirrhosis.
- Single Tablet Regimen: Harvoni is a single-tablet regimen that combines two antiviral drugs, Ledipasvir and Sofosbuvir, eliminating the need for interferon or ribavirin for the majority of patients.
- Reduced Treatment Duration: For many patients, treatment can be finished in 8 to 12 weeks, which is much shorter than previous treatment alternatives.
- Well-Tolerated: Harvoni is usually well-tolerated, with the most frequent adverse effects being fatigue and headache.
How to Use Harvoni (Ledipasvir / Sofosbuvir)?
- Harvoni is taken once a day, with or without meals.
- You must take Harvoni exactly as directed by your healthcare professional for the whole duration of the therapy, even if your symptoms improve.
- Do not change your dose or stop taking Harvoni without first consulting your doctor.
Important Safety Information about Harvoni
- Before beginning Harvoni, tell your doctor about all of your medical conditions, especially whether you have hepatitis B, liver disorders other than hepatitis C, or have undergone a liver transplant.
- Inform your doctor about all of the medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements. Harvoni can interact with other medications, resulting in serious side effects.
- The most common Harvoni side effects are weariness and headache. Serious adverse effects are uncommon but may occur.
Fact Table for Harvoni
| Facts | Details |
| Generic Name | Ledipasvir/Sofosbuvir |
| Brand Name | Harvoni |
| Approved By | FDA (Food and Drug Administration) |
| Date of Approval | October 2014 |
| Indications | Treatment of chronic Hepatitis C virus (HCV) genotypes 1, 4, 5, and 6 in adults and children over 3 years of age |
| Dosage Form | Oral tablet |
| Strengths | 90 mg Ledipasvir/400 mg Sofosbuvir |
| Recommended Dosage | One tablet daily |
| Treatment Duration | 8, 12, or 24 weeks, depending on patient-specific factors including the presence of cirrhosis, treatment history, and viral genotype |
| Mechanism of Action | Ledipasvir is an NS5A inhibitor, and Sofosbuvir is a nucleotide polymerase inhibitor. Together, they prevent the hepatitis C virus from multiplying and spreading. |
| Cure Rate | Up to 99% in some patient populations with HCV genotype 1, 4, 5, or 6, depending on specific factors such as treatment history and presence of cirrhosis |
| Common Side Effects | Fatigue, headache |
| Drug Interactions | Significant interactions with amiodarone, anticonvulsants, antituberculous agents, herbal supplements like St. John’s Wort, and HIV antiviral regimens |
| Contraindications | Known hypersensitivity to Ledipasvir, Sofosbuvir, or any component of the formulation |
| Pregnancy Category | Category B (No evidence of risk in humans) |
Common Side Effects of Harvoni
Like all medications, Harvoni (Ledipasvir / Sofosbuvir) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Fatigue
- Headache
- Nausea
- Insomnia
- Cough
If you experience any of these side effects or others, make sure to discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Harvoni (Ledipasvir / Sofosbuvir)?
You can order Harvoni (Ledipasvir / Sofosbuvir) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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