Simparica Trio (Sarolaner / Moxidectin / Pyrantel Pamoate)

Simparica Trio is the all-in-one answer for dog owners. It provides unmatched protection against the most common and hazardous pests and parasites by combining the powerful effects of Sarolaner, Moxidectin, and Pyrantel Pamoate.

Why Choose Simparica Trio (Sarolaner / Moxidectin / Pyrantel Pamoate)?

  • Broad Spectrum Protection: Provides full protection against fleas, ticks (including those that can transmit Lyme disease), heartworms, roundworms, and hookworms.
  • Rapid Action: Kills fleas within three hours and ticks within eight hours of ingestion.
  • Long-Lasting: A single dose gives a full month of protection to keep your dog safe and healthy.
  • Convenience: Replaces the need for many drugs with a single, easy-to-administer chewable tablet.
  • Safety: Formulated for dogs and pups as young as 8 weeks old and weighing at least 2.8 pounds.

How to Use Simparica Trio (Sarolaner / Moxidectin / Pyrantel Pamoate)?

  • Correct Dosage: The dosage of Simparica Trio is determined by your dog’s weight. Make sure you’re using the appropriate strength for your dog’s weight range. If you’re unsure, talk to your veterinarian.
  • Simparica Trio is a monthly, chewable tablet that should be taken orally. It may be given with or without food. For picky eaters, you can mix the chewable with food or give it directly to the dog.
  • Use one Simparica Trio chewable once a month. This constant regimen provides continual protection against fleas, ticks, heartworms, roundworms, and hookworms.
  • Monitoring: After administering the tablet, watch your dog for a few minutes to ensure it is swallowed. If you’re not sure if the entire dose was consumed, it’s okay to administer another full dose.

Important Safety Information about Simparica Trio

  • Simparica Trio is licensed for use in dogs aged 8 weeks and up, weighing at least 2.8 pounds.
  • Pregnant, breeding, or nursing dogs should consult with their veterinarian before using Simparica Trio.
  • Allergic Reactions: Be on the alert for signs of an allergic response, including hives, swelling, or difficulty breathing, and contact your veterinarian right once if they occur.
  • Interaction with Other Medications: If your dog is presently taking medicine, including supplements, consult your veterinarian to avoid any interactions.

Fact Table for Simparica Trio

Facts Detail
Product Name Simparica Trio
Active Ingredients Sarolaner, Moxidectin, Pyrantel Pamoate
Indications – Prevention of heartworm disease (caused by Dirofilaria immitis) – Treatment and control of tick and flea infestations- Treatment and control of roundworms and hookworms
Species Dogs
Formulation Chewable tablets
Dosage Administered orally, once a month. The dosage is based on the dog’s weight.
Weight Classes Available in different strengths for dogs of various weight ranges.
Efficacy Begins killing fleas within 4 hours and ticks within 8 hours of administration. Prevents heartworm disease when used monthly.
Safety Information – Not for use in humans – Keep out of reach of children – Use with caution in dogs with a history of seizures
Side Effects May include vomiting, diarrhoea, lethargy, and decreased appetite.
Contraindications Should not be used in puppies less than 8 weeks old or dogs weighing less than 2.8 lbs.
Administration Oral
Storage Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F).

Common Side Effects of Simparica Trio

Like all medications, Simparica Trio (Sarolaner / Moxidectin / Pyrantel Pamoate) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.

  • Vomiting
  • Diarrhea
  • Lethargy
  • Decreased appetite

If you experience any of these side effects or others, make sure to discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.

How Can You Buy Simparica Trio (Sarolaner / Moxidectin / Pyrantel Pamoate)?

You can order Simparica Trio (Sarolaner / Moxidectin / Pyrantel Pamoate) using these methods on our website:

  1. Order Online
  2. Order by Phone
  3. Order by Fax
  4. Order your refills

Visit our How to order page.

Interest-Free Payments

4 INSTALLMENTS, 6 WEEKS, 0% INTEREST

PharmaServe now offers you the option to make 4-interest-free payments by credit card once your order is confirmed using

EV SSL Encrypted

Stay informed and healthy! Sign up and never miss out on valuable health insights directly to your inbox


* indicates required


Dr. Conor Sheehy, PharmD, BCPS is a practicing clinical pharmacist that works in primary care. He supports other members of the healthcare team including physicians, mid-level providers, nurses, and other clinical staff. He also likes to use his drug knowledge to inform his patients and the public about the benefits and risks they can expect from their medications. His clinical specialties include: anticoagulation, diabetes management, and psychiatric care.
View Linkedin profile

Please note that due to government rules and regulations, orders may not exceed 3 months in supply.
Please call 1-800-258-0477 or email us if you have any questions or concerns.