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Xadago (Safinamide Mesylate)
Xadago (Safinamide Mesylate) enhances dopaminergic activity while selectively blocking Monoamine Oxidase B (MAO-B), which aids in the breakdown of dopamine in the brain, increasing its availability. It also inhibits sodium and calcium channels, which could explain its effects on motor symptoms and neuroprotection.
Why Choose Xadago (Safinamide Mesylate)?
- Reduced “off” time: Patients had longer periods of better motor performance.
- Simple to use: Take once daily, with or without food.
- Dual Mechanism: Offers an innovative approach by increasing dopamine levels while also contributing to the reduction of excitotoxicity, potentially protecting neuronal function.
How to Use Xadago (Safinamide Mesylate)?
- Begin with a 50 mg tablet once daily, which can be increased to a 100 mg tablet depending on response and tolerance.
- Xadago® may be taken with or without food.
- It is critical not to exceed the recommended dosage and to seek the advice of a healthcare provider.
Important Safety Information about Xadago
- Xadago® is not suitable for everyone. Patients with severe liver disease, as well as those using other MAO inhibitors or opioids, should avoid this medication.
- Inform your doctor about all medications you are taking, since there may be substantial interactions.
- This medicine may have a sedative effect that affects your ability to drive or operate machinery.
Fact Table for Xadago
| Facts | Details |
| Generic Name | Safinamide Mesylate |
| Brand Name | Xadago® |
| Approved Use | Adjunctive treatment for Parkinson’s Disease with “off” episodes |
| FDA Approval Year | 2017 |
| Dosage Forms | 50 mg and 100 mg tablets |
| Administration Route | Oral |
| Dosage | Initial dose of 50 mg once daily, adjustable to 100 mg based on response and tolerability |
| Mechanism of Action | MAO-B inhibition, dopamine reuptake inhibition, and sodium and calcium channel blocking |
| Primary Indication | Parkinson’s disease |
| Key Benefits | Reduces “off” time, taken once daily, dual mechanism of action |
| Common Side Effects | Insomnia, nausea, dizziness |
| Contraindications | Severe liver impairment, concurrent use with other MAO inhibitors or opioids |
| Drug Interactions | Pethidine, dextromethorphan, other MAO inhibitors, selective serotonin reuptake inhibitors |
| Warning and Precautions | Potential for hypertensive crisis, serotonin syndrome, impulse control disorders |
Common Side Effects of Xadago
Like all medications, Xadago (Safinamide Mesylate) can cause side effects, although not everybody gets them. Understanding these side effects can help you use this medication safely and effectively.
- Insomnia
- Nausea
- Dizziness
If you experience any of these side effects or others, make sure to discuss them with your healthcare provider. They can offer advice and may adjust your treatment if necessary. Report any severe or unexpected side effects immediately.
How Can You Buy Xadago (Safinamide Mesylate)?
You can order Xadago (Safinamide Mesylate) using these methods on our website:
- Order Online
- Order by Phone
- Order by Fax
- Order your refills
Visit our How to order page.
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